在小鼠的背前乳头核和后皮层中,协调的头部方向表示
Marie-Sophie H van der Goes1, Jakob Voigts1,2,3, Jonathan P Newman2,4
1Department of Brain & Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.
大脑的头部方向 (HD) 系统使用视觉线索快速更新. 这项研究揭示了HD在后皮质和背前丘脑中近同步的HD表现,这对空间导航至关重要.
科学领域:
- 神经科学是一个神经科学.
- 空间导航 空间导航
- 系统神经科学 系统神经科学
背景情况:
- 强大的方向感对于生存至关重要,它结合了自我运动和外部感官信息.
- 视觉线索更新头部方向 (HD) 表示的机制尚未完全理解.
- 后皮质 (RSC) 对于空间表现至关重要,并编码高清信息.
研究的目的:
- 调查RSC和thalamus (ADn) 的背前核之间的HD表示的时间动态和协调.
- 阐明视觉线索在更新高清表示中的作用.
- 检查HD信息流的基础上的解剖和功能连接.
主要方法:
- 在动物身上同时进行了两区域四极管记录.
- 在RSC和ADn中监测了HD的表现,在视觉暗示旋转和在黑暗中进行监测.
- 评估了ADn和RSC之间的解剖学和功能连接.
主要成果:
- 发现RSC中的HD表示与ADn中的HD表示几乎同步,即使在视觉提示旋转期间也是如此.
- 即使在没有视觉线索 (黑暗) 的情况下,RSC和ADn之间的这种协调也保持不变.
- 连接性分析支持强烈的HD信息从ADn到RSC的前驱动,反有限.
结论:
- 这些发现表明,需要协调,全球更新HD参考框架,跨越thalamus和皮质.
- 这种协调活动确保了稳定而准确的方向感,这对于空间定向至关重要.
- 结果强调了ADn-RSC途径在整合用于导航的感官信息方面的重要性.
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