在现实实践中多发性肌痛风湿的结果:一个纵向队列研究
Mehran Rahimi1, Kamal Esalatmanesh2, Sara Daneshvar1
11Connective Tissue Diseases Research Center, Tabriz University of Medical Science, Iran.
概括
多发性肌痛类风湿症 (PMR) 患者经常能够迅速控制症状,大多数患者达到持续缓解. 然而,经常需要长期治疗,并且坚持影响复发率.
科学领域:
- 类风湿病学 类风湿病学
- 临床免疫学临床免疫学
- 流行病学 流行病学
背景情况:
- 多发性肌痛性风湿症 (PMR) 是一种炎症状况,与巨细胞动脉炎密切相关.
- 了解PMR中缓解的现实结果和预测因素对于患者管理至关重要.
研究的目的:
- 调查PMR患者队列中的持续缓解和其他结果.
- 确定影响PMR症状缓解,缓解,复发和疾病损伤的因素.
主要方法:
- 来自塔布里兹医学科学大学血管炎注册局 (TUOMS-VR) 的81名PMR患者的纵向研究.
- 评估的结果包括持续缓解,无葡萄糖皮质醇缓解,无药物缓解,复发率和疾病诱导的损伤.
- 患者被跟踪到2023年2月,随访时间中位数为57个月.
主要成果:
- 98.8%的患者在3周内实现了症状控制,86.4%的患者在9周内实现了持续缓解.
- 持续缓解在非吸烟者和坚持治疗的患者中更为频繁.
- 复发发生在22.1%的患者中 (通常是由于不坚持),无药物缓解在30.9%,损伤在42.0%的患者中.
结论:
- 在日常的PMR实践中可以实现持续缓解,大多数患者在最后一次诊断时处于缓解状态.
- 尽管缓解率很高,但大约三分之二的PMR患者需要长期治疗.
- 患者的坚持和吸烟状态是影响PMR结果的重要因素.
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