在ADHD患者的药物治疗和死亡率
Lin Li1, Nanbo Zhu1, Le Zhang1
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
JAMA
|March 12, 2024
概括
在瑞典,开始治疗注意力缺陷/多动症 (ADHD) 的药物治疗与两年内全因死亡率的显著降低有关. 这种ADHD药物治疗的好处在非自然死亡中尤为显著.
科学领域:
- 精神病学
- 公共卫生
- 药理学
背景情况:
- 注意缺陷/多动症 (ADHD) 与死亡风险增加有关.
- ADHD药物治疗对死亡风险的影响尚不清楚.
研究的目的:
- 研究是否启动ADHD药物治疗可以降低被诊断为ADHD的个体的死亡风险.
主要方法:
- 在瑞典使用目标试验模拟框架的全国性观察队列研究.
- 包括6-64岁的被诊断患有ADHD的人 (2007-2018) 和没有先前的药物治疗.
- 在诊断后2年内评估所有死因,自然死因和非自然死因.
主要成果:
- 在148,578名ADHD患者中,56.7%的人开始服用药物.
- 药物开始与所有原因死亡率显著降低 (HR,0. 79).
- 开始治疗显著降低了非自然死亡率 (HR,0.75),但并没有降低自然死亡率.
结论:
- 开始服用ADHD药物与全因死亡率显著降低有关.
- 在非自然死亡方面,死亡率的降低尤为明显.
- 结果表明ADHD药物治疗可能有死亡益处.
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