小细胞肺癌的不断变化的风景
Giordano Fabricio Cittolin-Santos1, Brendan Knapp1, Bharath Ganesh2
1Division of Oncology, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.
Cancer
|March 12, 2024
概括
小细胞肺癌 (SCLC) 的发病率在1988年达到顶峰,自那以后一直在下降. 虽然存活率略有改善,但人口统计学转变显示患者人口老龄化,SCLC诊断的女性越来越多.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 小细胞肺癌 (SCLC) 以其侵略性而闻名,其特点是细胞的快速生长和早期传播.
- 了解人口趋势和患者结果对于有效的SCLC管理至关重要.
研究的目的:
- 分析SCLC发病率,人口统计,分期和存活率的趋势.
- 提供近五十年来SCLC不断变化的景观的见解.
主要方法:
- 使用了国家癌症研究所的监测,流行病学和最终结果 (SEER) 数据库.
- 分析了从1975年到2019年的数据,使用结点分析来确定SCLC发病率,患者特征和生存结果的趋势.
主要成果:
- SCLC发病率在1986年达到峰值,到2019年下降,其在所有肺癌中的比例也在下降.
- 诊断时的中位数年龄增加,被诊断为SCLC的女性比例显著增加.
- 第四阶段的诊断变得越来越普遍,虽然1年和5年生存率有所改善,但这种增加很小.
结论:
- 自从上世纪80年代末达到顶峰以来,SCLC的发病率已经下降.
- 主要的人口变化包括老年患者人口和更高比例的女性被诊断.
- 对于SCLC患者来说,生存率的改善在统计上是显著的,但在临床上是有限的,这凸显了进一步治疗进展的必要性.
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