在VSMC中激活IKK2 / NF-κB通路可抑制CKD中化的血管硬性

相关实验视频

Updated: Jul 1, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.5K

Shinobu Miyazaki-Anzai, Masashi Masuda, Audrey L Keenan

    JCI insight
    |March 12, 2024
    PubMed
    概括

    血管光滑肌细胞中的IKK2 / NF-κB通路激活通过减少细胞死亡和细胞外囊泡矿化来防止慢性病引起的血管化和性.

    关键词:
    心血管疾病是什么心血管疾病慢性脏疾病 慢性脏疾病在 NF-kappaBB 里.血管生物学 血管生物学

    更多相关视频

    Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models09:01

    Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

    Published on: January 27, 2023

    1.7K
    Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro05:47

    Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

    Published on: May 10, 2021

    4.0K

    相关概念视频

    Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

    Antihypertensive Drugs: Action of Calcium Channel Blockers

    Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
    517
    Calmodulin-dependent Signaling01:16

    Calmodulin-dependent Signaling

    Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
    The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
    5.1K
    MAPK Signaling Cascades01:07

    MAPK Signaling Cascades

    Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
    5.5K
    NF-κB-dependent Signaling Pathway02:26

    NF-κB-dependent Signaling Pathway

    The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
    NF-κB-dependent Signaling Mechanism
    The...
    7.4K
    The JAK-STAT Signaling Pathway01:20

    The JAK-STAT Signaling Pathway

    Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
    8.9K