挫折可以通过基因复制和专业化限制乱伦酶的适应
Michael Schmutzer1,2, Pouria Dasmeh3, Andreas Wagner4,5,6
1Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.
Journal of molecular evolution
|March 12, 2024
概括
酶杂交,催化多个反应的能力,通常导致通用或专业酶,而不是中间体. 一个新的模型表明,酶是酶.
科学领域:
- 生物化学 生物化学
- 酶动力学 酶动力学
- 进化生物学是进化的生物学.
背景情况:
- 大多数酶都催化了多种反应 (酶杂交).
- 一般性酶与专业性酶的分布以及影响因素尚不清楚.
- 了解酶进化需要描述乱伦模式.
研究的目的:
- 为了研究酶乱交的分布 (通用主义者与专家).
- 确定影响酶专业化演变的因素.
- 为了模拟乱交酶的进化动态.
主要方法:
- 来自BRENDA数据库的实证酶数据的分析.
- 开发一种基于约束的酶进化的计算模型.
- 在选择压力下模拟酶复制和亚功能化.
主要成果:
- 经验性酶乱交表现出双模分布:酶主要是通用或专业的,中间体很少.
- 只有酶生物物理学无法解释这种双模分布.
- 基于约束的模型成功地预测了观察到的双模分布.
- 相互矛盾的约束和选择压力会导致"丧"状态,阻碍专业化.
- 挫折的可能性随着催化反应的数量增加而增加.
结论:
- 酶乱交分布是由进化压力形成的,这种压力有利于泛化或专业化.
- 亚功能化是可能的,但在某些酶系统中受到限制.
- 由相互矛盾的进化需求引起的酶丧,在酶进化中起着重要作用.
- 自然选择可能会因为减少丧而有利于更简单的催化酶.
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