系统性红斑狼患者的视觉相关生活质量
Francisco de Asís Bartol-Puyal1,2,3, María Chacón González1,2, Borja Arias-Peso1,2
1Ophthalmology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
Healthcare (Basel, Switzerland)
|March 12, 2024
概括
系统性红斑狼 (SLE) 患者在接受氧化 (HCQ) 治疗时报告,由于疾病活动和较低的健康状况,与视力相关的生活质量 (VRQoL) 降低. 年龄,BMI和视力敏等因素也会影响VRQoL.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 生活质量研究 研究 生命质量研究
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,可以影响多个器官.
- 氧化 (HCQ) 是一种常见的SLE治疗方法,但其对视力的长期影响令人担忧.
- 与视力相关的生活质量 (VRQoL) 是慢性疾病患者的重要结果指标.
研究的目的:
- 在没有眼科疾病的情况下,用HCQ治疗的SLE患者中评估VRQoL.
- 在这个患者群体中确定影响VRQoL的因素.
- 为了比较SLE患者和健康对照者之间的VRQoL.
主要方法:
- 横截面研究比较SLE患者 (按疾病持续时间分组) 和健康对照.
- 眼科评估包括希尔默测试,最佳校正视敏度 (BCVA),轴长 (AL) 和OCTA.
- 验证的问卷:视力障碍的影响 (IVI) 和狼影响追踪器 (LIT).
主要成果:
- 与健康对照组相比,SLE患者报告VRQoL较差.
- 线性回归确定了血清费里,SLE活性,BMI,年龄和BCVA作为影响VRQoL的重要因素.
- LIT分数与IVI问卷中的两个类别相关.
结论:
- 在HCQ治疗中,SLE患者的VRQoL降低,主要是由疾病活动和整体健康状况驱动的,即使没有明显的眼睛疾病.
- 年龄,BMI和BCVA也会导致VRQoL降低.
- 疾病活动的影响可能会掩盖其他潜在的眼科贡献者,如干眼.
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