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Updated: Jul 1, 2025

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基于网络药理学和分子对接的猪原的低血糖的探索

Fating Zhou1, Di Li1, Yakun Hou2

  • 1College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, China.

PloS one
|March 12, 2024
PubMed
概括

一种新的猪原,NWYR,通过抑制α-葡萄糖酶和向DPP4,显示出对治疗2型糖尿病的显著潜力. 进一步的研究将验证其低血糖效应和机制.

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Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
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