确定泰国儿科人口的特定年龄和性别血清肌素参考范围
Sakon Suwanrungroj1, Parichart Pattarapanitchai2, Sirinart Chomean3,4
1Queen Sirikit National Institute of Child Health, Thung Phayathai Subdistrict, Ratchathewi, Bangkok, Thailand.
PloS one
|March 12, 2024
概括
这项研究为泰国儿童建立了关键的年龄和性别特定的血清肌素参考范围. 这些新的儿科功能基准提高了当地人口的诊断准确性.
科学领域:
- 儿科脏病学 儿科脏病学
- 临床生物化学 临床生物化学
- 生物统计学 生物统计学
背景情况:
- 准确评估儿童的功能需要特定于年龄和性别的血清肌素参考范围.
- 现有的参考值,通常是基于成年人或不同族群的,对于儿科患者群体可能缺乏准确性.
- 在泰国儿科人口中存在局部诊断标准的需求.
研究的目的:
- 在泰国儿科人口中建立血清肌氨酸的特定,年龄和性别分层的参考范围.
- 解决目前用于评估泰国儿童功能的参考值不足的问题.
- 为改善泰国儿科脏病治疗提供本地化诊断基准.
主要方法:
- 追溯分析了2017-2021年泰国儿童 (新生儿至18岁) 的27,642个血清肌素测量结果.
- 使用Bhattacharya方法来确定参考范围,按年龄组和性别分层.
- 与国际研究 (Schlebusch H.,Pottel H.,Chuang GT.) 进行了新得出的范围比较. 为了验证.
主要成果:
- 为泰国儿童建立了不同的血清肌素参考范围,根据年龄和性别有很大差异.
- 观察到血清肌素水平随着年龄的增长逐渐增加,从2个月到18岁.
- 与其他种族人口的参考值相比,确定了显著的差异.
结论:
- 成功为泰国儿童建立了量身定制的血清肌素参考范围,增强了对脏健康的诊断工具.
- 这项研究代表了泰国儿科脏病学的重大进展.
- 建议不断完善这些范围,并进一步研究儿科功能评估.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
91
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
91
01:23Renal Clearance
932
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
932
01:07Determination of Renal Drug Clearance: Graphical and Midpoint Methods
116
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
116
01:08Renal Drug Clearance: Comparison Between Renal Excretion Methods
135
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
135
01:11Renal Failure: Dose Adjustments
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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
88