跨男性和半性别青少年的白质微观结构:一个多参数和多变量研究
Lindsey T Thurston1, Malvina N Skorska2, Nancy J Lobaugh3,4
1Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada.
PloS one
|March 12, 2024
概括
青少年白质微观结构在 cisgender 男孩, cisgender 女孩和跨性别男孩之间有所不同. 轴扩散度 (AD) 和T1放松时间显示了与发育变量相关的独特模式,突出了性别和性别对大脑发育的影响.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 放射学 放射学是一门学科.
背景情况:
- 青春期是大脑发育的关键时期,特别是白质 (WM) 微观结构.
- 了解青少年大脑发育中的性别和性别差异对于确定神经发育轨迹至关重要.
研究的目的:
- 使用多参数映射来表征青少年WM微观结构.
- 研究扩散张力成像 (DTI) 指数,定量T1放松计和 cisgender 女孩, cisgender 男孩和跨性别男孩的发育变量之间的关系.
主要方法:
- 使用的扩散张力指数 (包括轴向扩散率[AD]) 和定量T1放松计.
- 采用基于路径的空间统计和多参数多变量分析.
- 研究了与发育变量之间的关联:年龄,血清雌激素,青春期发育和性吸引力.
主要成果:
- 观察到AD的群体差异.
- 在不同组中,较高的AD与较长的T1放松时间相关.
- WM微观结构显示,与 cisgender 男孩相比,与 cisgender 女孩和跨性别男孩相比,与发展变量有更强的关联.
- 与性吸引相关的AD,与雌激素相关的T1,具有特定群体的模式.
结论:
- 青少年的WM发展因性别和性别认同而异.
- 观察到的大脑模式可能表明髓化和组织密度的差异,特别是在 cisgender 男孩.
- 发育轨迹对于理解与性,性别和性吸引有关的神经结构变异至关重要.
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