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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Updated: Jul 1, 2025

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SARS-CoV2引发了结构性大脑变化,导致执行功能下降.

Daniel Deuter1, Katharina Hense1, Kevin Kunkel1

  • 1Klinik und Poliklinik für Neurochirurgie, University Hospital Regensburg, Regensburg, Germany.

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|March 12, 2024
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概括

COVID-19导致灰色和白色物质的神经质变化,影响执行功能和语言至关重要的大脑网络. 这些变化在急性患者中观察到,并且可以在康复后持续存在,影响认知能力.

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科学领域:

  • 神经科学是一个神经科学.
  • 放射学 放射学是一门学科.
  • 认知科学 认知科学

背景情况:

  • COVID-19被认为是一种多系统性疾病,具有显著的中枢神经系统 (CNS) 影响.
  • 目前对COVID-19神经功能影响的理解缺乏全面的疾病模型.
  • 研究主要集中在直接的病毒效应 (神经缩) 上,而不是更广泛的神经可塑性变化.

研究的目的:

  • 为了研究与COVID-19相关的灰色和白色物质的神经质变化.
  • 为了将观察到的大脑结构变化与神经认知测试结果相关联.
  • 基于神经功能变化的COVID-19多维疾病模型的开发.

主要方法:

  • 前性研究包括急性疾病COVID-19患者 (n=16),康复患者 (n=21) 和健康对照 (n=13).
  • 使用磁共振成像 (MR):T1加权序列用于灰质的基于声素的形态测量和扩散加权序列用于白质的概率学图谱.
  • 进行了全面的神经认知测试,评估了语言和非语言领域.

主要成果:

  • 在前端-基底 - thalamus网络和部区域的灰质中发现了显著的变化,以及连接白质纤维通道.
  • 急性COVID-19患者表现出灰质体积和白质通道完整性的减少.
  • 在急性患者中观察到认知缺陷,特别是在执行功能和口语流方面,在康复的个体中仍然存在一些缺陷.

结论:

  • COVID-19中的结构性大脑变化涉及执行控制和语言至关重要的网络中的灰质体积和白质道.
  • 为了充分理解这些变化,特别是关于它们的长期影响和"后COVID综合征"现象,进一步的研究是必不可少的.