系统性硬化症患者中与身体功能相关的因素:SPIN队列横截面研究
Tiffany Dal Santo1,2, Danielle B Rice3,4, Marie-Eve Carrier1
1Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Rheumatology (Oxford, England)
|March 12, 2024
概括
与普通人群相比,患有全身性硬化症 (SSc,硬化皮质) 的个体的身体功能明显受损. 年龄,吸烟和特定疾病表现等因素与SSc患者的身体功能下降有关.
科学领域:
- 类风湿病学 类风湿病学
- 临床医学 临床医学
- 患者报告的结果
背景情况:
- 系统性硬化症 (Systemic Sclerosis,SSc),也称为硬皮症,是一种慢性自身免疫性疾病,其特征是纤维化,血管异常和免疫失调.
- 身体功能受损是SSc的常见和使人虚弱的并发症,严重影响患者的生活质量和日常活动.
研究的目的:
- 将SSc患者的身体功能与美国普通人口的规范数据进行比较.
- 确定与SSc.体能功能障碍相关的社会人口学,生活方式和疾病特异性因素.
主要方法:
- 利用了2385名参与者在以患者为中心的干预网络队列中的数据.
- 使用患者报告结果测量信息系统版本2 (PROMIS v2) 评估身体功能. 身体功能领域.
- 采用多变量线性回归来分析各种因素和物理功能的T分数之间的关联.
主要成果:
- SSc参与者平均身体功能T-score为43.7 (SD=8.9),大约三分之二的标准偏差低于一般人群平均值 (50,SD=10).
- 相关因素包括年龄较大,女性性别,教育程度较低,吸烟,BMI较高,扩散的SSc亚型,胃肠道干扰,数字,关节收缩 (大小),间歇性肺病,肺动脉高血压和同时发生的类风湿性关节炎或异常性炎症性肌肉炎.
- 酒精消费与身体功能有积极的关联.
结论:
- 显而易见地,在很大一部分患有系统性硬化症的人群中,身体功能受到损害.
- 多种因素,包括社会人口统计学,生活方式和与疾病相关的变量,独立地与SSc的身体功能下降有关,突出显示了管理这种疾病的复杂性.
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