乌拉圭多发性硬化症的发病率:基于人口的前性研究
Valeria Rocha1, Noelia Sorondo1, Fabián Gómez1
1Institute of Neurology, Hospital de Clínicas, University of the Republic, Montevideo, Uruguay.
Neuroepidemiology
|March 12, 2024
概括
乌拉圭的多发性硬化症 (MS) 发病率正在增加,每10万人/年发病率为3.18例. 这项研究突出了日益增长的趋势和晚发性MS的显著发病率.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 全球多发性硬化症 (MS) 发病率估计在每10万人/年0.5-10之间,并且正在增加.
- 2014年之前的一项研究估计乌拉圭的MS发病率为每10万人/年1.2人.
研究的目的:
- 通过基于人口的研究来确定乌拉圭多发性硬化症 (MS) 的发病率.
- 更新乌拉圭的MS发病率之前的估计.
主要方法:
- 在乌拉圭从2019年7月到2021年6月进行了一项观察性,前性,基于人口的研究.
- 多发性硬化症的诊断遵循了2017年麦当劳标准.
- 采用捕获-重新捕获方法,利用多个数据源来确保全面的病例识别.
主要成果:
- 确认了155例新的多发性硬化病例.
- 使用捕获-重新捕获方法的估计发病率为每10万人年3.18 (95% CI:3.02-3.34).
- 女性 (3.95) 的发病率高于男性 (1.72),平均年龄为35岁,8.38%的患者被诊断为晚发性MS.
结论:
- 乌拉圭的MS发病率较低,但在拉丁美洲相对较高 (2.0-3.99),与全球增长趋势保持一致.
- 乌拉圭MS病例的年龄和性别分布与国际调查结果一致.
- 该研究证实了晚发性MS的高发病率,并验证了捕获-重新捕获方法的详尽调查.
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