附骨架常规骨髓瘤的整体存活率的预后因素
Phakamani G Mthethwa1, Leonard C Marais2, Collen M Aldous3
1Department of Orthopaedic Surgery, Dr Pixley Ka Isaka Seme Memorial Hospital, University of KwaZulu-Natal, Nelson Mandela School of Clinical Medicine, Durban, South Africa.
Bone & joint open
|March 12, 2024
概括
高度骨髓瘤总生存率 (OS) 较低的预测因素包括年龄较小,症状持续时间较长,诊断时转移,性酸酶升高和息治疗. 绝对的手术和治疗治疗是保护因素,改善了四肢骨髓瘤患者的生存状况.
科学领域:
- 整形瘤学 整形瘤学
- 癌症预后 癌症预后
- 流行病学 流行病学
背景情况:
- 肢体高度常规骨髓瘤是一种具有挑战性的诊断,预后可变.
- 确定总生存率 (OS) 的预测因素对于有效的患者管理和治疗策略至关重要.
研究的目的:
- 确定整体生存 (OS) 的预测因素,并确定与肢体高度常规骨髓瘤患者预后不佳相关的因素.
- 分析南非单中心队列中的预后因素.
主要方法:
- 77名患者的回顾性横截面分析,随访时间至少为3年.
- 使用考克斯比例回归模型和卡普兰-梅尔方法进行统计分析,以确定OS的预后因素.
主要成果:
- 糟糕的生存系统的预测因素包括年龄较小 (≤19岁),症状持续时间较长 (≥5个月),诊断时转移 (Enneking阶段III),性酸酶增加,息治疗和截肢.
- 确定的手术和治愈治疗被确定为对不良生存状况的保护因素.
- 平均寿命为24个月,3年生存率为57.1%,预计5年生存率为29.8%.
结论:
- 在这个南非队列中,呈现时的转移是常见的 (58.4%),与5年的贫困生存率为29.8%相关.
- 年龄较小,症状持续时间较长,转移性疾病,性酸酶升高,以及息治疗对生存有负面影响.
- 确定的手术干预和治愈治疗策略对于改善四肢骨髓瘤的结果至关重要.
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