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肥胖儿童的塞马格卢提德治疗:一项观察性研究
Elizabeth-Jane van Boxel1, Saqib Rahman2, Karen Lai3
1Southampton General Hospital, Southampton, UK elizabeth.vanboxel@uhs.nhs.uk.
Archives of disease in childhood
|March 12, 2024
概括
塞马格卢提德有效地降低了肥胖和并发疾病的儿童的体重和BMI. 发现了轻微的胃肠道副作用,很少有人停止治疗.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 肥胖医学 肥胖医学
- 药理干预药理干预
背景情况:
- 儿童肥胖是一个日益严重的全球健康问题.
- 伴随性疾病如胰岛素抵抗和2型糖尿病在儿童肥胖中很常见.
- 有效的体重管理策略对于儿童的长期健康结果至关重要.
研究的目的:
- 评估塞马格卢提德在肥胖儿科患者减肥方面的疗效和耐受性.
- 评估赛马格卢提德对体重指数 (BMI) 标准偏差得分 (SDS) 和整体体重的影响.
- 在这个人群中识别和报告与塞马格卢提德治疗相关的任何不良事件.
主要方法:
- 一项回顾性观察性研究包括50名患有肥胖症 (BMI SDS>2) 和并发症的儿童 (年龄为10-18岁).
- 患者每周接受一次注射性塞马格卢提德 (1毫克),以及饮食和生活方式建议.
- 主要结局包括体重变化,BMI SDS和6个月和12个月的百分比体重.
主要成果:
- 6个月后,BMI SDS (0.32±0.27) 和体重 (7.03±7.50公斤) 显著减少,平均体重减轻6.4±6.3%.
- 在12个月后,BMI SDS (0.54±0.52) 和体重 (9.7±10.8公斤) 进一步显著下降,总体重减轻8.9±10.0%.
- 轻微的胃肠道副作用很常见;五名患者因不良事件而停止治疗,一名患者患上了胆结石.
结论:
- 塞马格卢提德在患有肥胖和并发症的儿童中显示出作为减肥辅助剂的有效性.
- 治疗一般耐受良好,在多学科环境下副作用可控.
- 塞马格卢提德是儿科体重管理计划中一个有前途的治疗选择.
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