在初级乳腺腺囊性癌症中NOTCH1表达的影响
Alireza Salem1,2, Yun Wu3, Qingqing Ding3
1Pathology, The University of Texas, Houston, Texas, USA as7027@cumc.columbia.edu.
Journal of clinical pathology
|March 12, 2024
概括
乳腺腺囊性癌 (AdCC) 中NOTCH1路径的改变与较大的瘤大小和复发率的增加相关. 这表明NOTCH1可能是侵略性AdCC的治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 病理学 病理学 病理学
背景情况:
- 腺性囊性癌 (AdCC) 是一种罕见的恶性瘤,起源于唾液类型腺体.
- AdCC的特征是MYB::NFIB融合和MYB过度表达.
- 在AdCC中,NOTCH1通路的改变越来越多地被识别出来,并且与预后不佳有关.
研究的目的:
- 调查NOTCH1路径变化与初级乳腺AdCC中的临床结果之间的相关性.
- 评估NOTCH1免疫反活性对乳腺AdCC的临床结果的预测价值.
主要方法:
- 对25例原发性乳腺AdCC病例的回顾性分析.
- 在FFPE截面上进行NOTCH1表达的免疫组织化学 (IHC) 染色.
- NOTCH1表达与瘤大小,复发,转移和无复发存活率的相关性.
主要成果:
- NOTCH1表达与较大的原发性瘤大小 (>15mm) 有正相关.
- 与NOTCH1-阴性病例 (21.5%) 相比,NOTCH1-阳性AdCC的复发/转移率 (63.6%) 更高.
- NOTCH1阳性与明显较低的无复发存活率 (33个月与129个月) 相关.
结论:
- 乳腺AdCC中NOTCH1过度表达 (≥20%) 与较大的瘤大小和积极的临床行为有关.
- NOTCH1通路的改变可以作为乳腺AdCC的预后生物标志物.
- NOTCH1抑制剂显示出作为乳腺AdCC治疗策略的潜力.
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