现场校准珠子的实体验证作为反散系数计算的参考
Yuning Zhao1, Gregory J Czarnota2, Trevor H Park3
1Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Ultrasound in medicine & biology
|March 12, 2024
概括
在现场的珠通过校准组织衰减来提高定量超声波 (QUS) 的准确性. 这种方法增强了疾病状态分类,提供了更可靠的诊断能力.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 超声波物理 超声波物理
背景情况:
- 传统的定量超声波 (QUS) 方法用于回散系数 (BSC) 估计,依赖于外部引用.
- 这些外部引用不能充分解释超声波衰减和通过中间组织的传输损失.
- 这种限制可以在疾病状态分类中引入显著的偏差,例如乳腺癌和脂肪肝疾病.
研究的目的:
- 评估在位 (Ti) 珠作为定量超声波 (QUS) 的校准目标的有效性.
- 为了减轻反向散射系数 (BSC) 估计上的衰减和传输损失影响,使用现场Ti珠.
- 评估QUS衍生参数的改进精度,例如有效散射直径 (ESD) 和有效声度 (EAC).
主要方法:
- 在子乳腺瘤中植入了2毫米的Ti珠作为放射性标记物和超声波校准源.
- 用额外的减弱层 (猪肚) 和没有额外的减弱层 (猪肚) 扫描瘤以模拟组织干扰.
- 计算QUS参数 (ESD,EAC) 的方法是使用在位Ti珠和传统的外部参考幻影的校准光谱.
主要成果:
- 与外部参考幻影相比,in situ Ti珠子方法在ESD和EAC估计中的偏差明显减少.
- 对于ESD,与Ti珠的95%置信区间为6.027.4,与幻影的114135.1相比.
- 对于EAC,95%的置信区间为Ti珠 -8.10.5和幻影 -41.5-32.2,表明一致性有所改善.
结论:
- 在现场的Ti珠有效地作为QUS的校准目标,补偿组织衰减和传输损失.
- 这种方法可以产生更准确的QUS估计,减少传统方法固有的偏差.
- 现场Ti珠校准方法在临床超声波应用中增强疾病状态分类的潜力.
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