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Updated: Jul 1, 2025

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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计算机辅助设计以提高阿尔多-基托减少酶KdAKRR的稳定性

Chen Dai1,2,3, Jia-Xin Tian1,2,3, Yu-Feng Chen1,2,3

  • 1Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, P. R. China.

Biotechnology journal
|March 12, 2024
PubMed
概括

计算机辅助设计提高了Kluyvermyces dobzhanskii的稳定性阿尔多基因还原酶 (AKR) 用于罗斯瓦斯塔丁合成. 经过工程设计的KdAKRM10突变体显示出更好的热稳定性和耐溶剂性,验证了设计策略.

关键词:
阿尔多-凯托减少酶计算机辅助设计是计算机辅助设计.有机溶剂耐受性 有机溶剂耐受性热稳定性 热稳定性

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