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超活跃突变在Mpro从SARS-CoV-2到药物耐药性的贡献

Julia M Flynn1, Sarah N Zvornicanin1, Tenzin Tsepal1

  • 1Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605, United States.

ACS infectious diseases
|March 12, 2024
PubMed
概括

耐药性SARS-CoV-2是一个令人担忧的问题. 这项研究发现,增加主要蛋白酶 (Mpro) 活性的"过活"突变是常见的,并有助于对关键抗病毒药物尼马特里尔维尔的抗药性.

关键词:
费特·弗雷特 (FRET FRET) 是一家在美国的船只.这就是SARS-CoV-2病毒.不同扫描光仪的差异扫描光仪.功能性得分 功能性得分质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量

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