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Updated: Jul 1, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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通过使用类结合抗体,通过Chaperone-Mediated Autophagy对细胞表面蛋白的有针对性的降解

Jinning Shao1, Xuefen Lin1, Haoting Wang1

  • 1Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, National Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou, China, 310058.

Angewandte Chemie (International ed. in English)
|March 12, 2024
PubMed
概括

研究人员开发了抗体-联体 (Ab-CMAs) 来降解细胞表面蛋白质. 这种新的方法利用伴侣介导的自 (CMA) 来除向蛋白质,显示了癌症治疗的前景.

关键词:
抗体 酸结合剂 抗体 酸结合剂细胞表面蛋白质 细胞表面蛋白质陪伴者介导的自生.溶酶体退化 溶酶体退化有针对性的蛋白质降解.

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