皮质白质的微观结构变化是精神分裂症中受损的马波段听觉平稳状态反应的基础
Daisuke Koshiyama1, Ryoichi Nishimura1, Kaori Usui1,2
1Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Schizophrenia (Heidelberg, Germany)
|March 13, 2024
概括
精神分裂症患者减弱的马波段听觉平稳状态反应 (ASSR) 与右半球皮质连接中白质完整性的破坏有关. 这表明改变的大脑网络可能是精神分裂症病理生理学的基础.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 马波段听觉平稳状态反应 (ASSR) 是精神分裂症的潜在生物标志物.
- 在精神分裂症中减少的马波段ASSR与认知和功能障碍相关.
- 减少马带ASSR的神经基质可能涉及广泛的皮质网络,特别是在右半球.
研究的目的:
- 为了研究马波段ASSR与白质完整性在精神分裂症的右额头,额头和尾皮质连接之间的关联.
- 为了澄清在精神分裂症患者中减少马带ASSR的基础的神经网络.
主要方法:
- 电脑电图 (EEG) 用于测量40 Hz的ASSR.
- 扩散张力成像 (DTI) 来评估白质的完整性 (微分异位性).
- 研究包括42名精神分裂症患者和22名健康对照.
主要成果:
- 在健康人群中,在研究的右半球连接中发现了马波段ASSR和白质完整性之间的正相关性 (未经校正的p=0.038).
- 这种正相关性在精神分裂症患者中没有显著意义 (未经校正的p=0.23).
结论:
- 这些发现支持这样一个假设:连接皮层区域的白质束对于马带ASSR生成至关重要.
- 精神分裂症中这些关系的破坏可能有助于观察到的马波段ASSR的减少.
- 减少的马波段ASSR可以作为精神分裂症的有价值的大脑标志物.
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