神经退行性疾病中的药用草药:关于抗氧化剂潜力的最新情况
Biplob Sarkar1, Nitasha Rana1, Charan Singh2
1Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, affiliated to IK Gujral Punjab Technical University, Jalandhar, 144603, Punjab, India.
Naunyn-Schmiedeberg's archives of pharmacology
|March 13, 2024
概括
药用草药治疗神经退行性疾病有望通过减少氧化应激和表现出抗亡作用来治疗神经退行性疾病. 这些天然化合物为传统治疗提供了潜在的更便宜和文化敏感的替代方案.
科学领域:
- 神经药理学神经药理学
- 传统医学的传统医学.
- 植物化学 植物化学
背景情况:
- 与传统医学相比,药用草药的疗效和副作用较少,是公认的.
- 传统的东亚医学有使用草药治疗神经问题的历史.
- 神经退行性疾病是复杂的,需要多方面的治疗方法.
研究的目的:
- 审查植物衍生的神经保护化合物在神经退行性疾病中的潜在治疗应用.
- 研究抗氧化植物化学物质的神经药理机制,包括它们对亡和炎症前兆的作用.
- 在临床前的神经毒性和动物模型中评估这些化合物的疗效.
主要方法:
- 从科学数据库中汇编和检查关于草本提取物,分数和化合物的研究.
- 在体,体外和体内对神经保护剂的研究.
- 对亡标志物 (caspase,Bax,Bcl-2) 和促炎标志物的影响分析.
主要成果:
- 植物衍生化合物通过减少大脑氧化应激和表现出抗丧性质来表现出神经保护作用.
- 许多研究证实了植物提取物和生物活性化合物对神经退行性疾病的疗效.
- 已识别的化合物调节了神经退行相关的关键标记物.
结论:
- 自然化合物通过多目标神经保护为预防和治疗神经退行性疾病提供了有希望的策略.
- 草药对数以百万计的人来说是一个可行的,具有成本效益和文化相关的治疗选择.
- 对神经药理机制的进一步研究可以为神经退行性疾病开辟新的治疗途径.
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