停止吸收的子在儿童的床上尿:一个随机对照试验
Anders Breinbjerg1,2, Konstantinos Kamperis3,4, Kristina Thorsteinsson5
1Department of Pediatrics, Aarhus University Hospital, Palle Juul-Jensens blvd. 99, 8200, Aarhus N, Denmark. andbre@clin.au.dk.
European journal of pediatrics
|March 13, 2024
概括
在患有严重夜间尿泡症 (NE) 的儿童中,停止使用吸收性睡衣 (APP) 导致湿夜减少. 然而,这种干预措施,
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 睡眠医学 睡眠医学
- 生活质量研究 研究 生命质量研究
背景情况:
- 严重的儿童夜间尿泡症 (NE) 影响了许多儿童,通常需要在夜间进行保护.
- 吸收性睡衣 (APP) 通常用于管理NE,但它们对自发解决方案的长期影响尚不清楚.
- 了解停止APP的影响对于指导儿科NE管理中的治疗决策至关重要.
研究的目的:
- 为了研究停止吸收性睡衣 (APP) 在患有严重夜间尿泡症 (NE) 的儿童中的疗效.
- 评估APP停止对湿夜率,生活质量 (QoL) 和睡眠的影响.
- 评估停止在儿科NE中使用APP的临床相关性和潜在副作用.
主要方法:
- 一个多中心,并行,随机对照试验,涉及105名儿童 (4-8岁) 患有严重的NE.
- 参与者接受了使用APP的4周试用期,然后随机选择继续或停止APP4-8周.
- 主要结局:在最后一周的干预期间,湿夜的差异;次要结局:质量和睡眠.
主要成果:
- 与继续服用的儿童相比,停止服用APP的儿童经历的湿夜显著减少 (2.3个夜晚少,p<0.0001).
- 在没有子的组中观察到~10%的完全解决率,在2周内观察到临床改善.
- 在延长期中,停用APP对QOL和睡眠产生了负面影响,但不是在核心4周期间;21%因压力而停用.
结论:
- 停止使用吸收性睡衣 (APP) 显示,严重夜间尿泡症 (NE) 的儿童湿夜的减少在统计上显著.
- 虽然观察到~10%的完全解决率,但临床相关性是有争议的,而且干预需要有动机的家庭.
- 停用APP可能会对生活和睡眠质量产生负面影响,应该谨慎处理,没有报告严重的副作用.
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