初级系统性血管炎中中风频率,相关因素和临床特征:一个多中心观察性研究
Ruth Geraldes1,2, Monica Santos3,4, Cristina Ponte5,6
1Neurology Department, Wexham Park Hospital, Frimley Health Foundation Trust, Slough, UK. ruth.geraldes@ndcn.ox.ac.uk.
大脑血管事件 (CVEs) 影响3.5%的初级系统性血管炎 (PSV) 患者在诊断时,比赫塞特病的发病率更高. 这些事件与传统的风险因素无关,并且复发率很高.
科学领域:
- 类风湿病学 类风湿病学
- 神经学 神经学
- 血管医学 血管医学
背景情况:
- 在初级系统性血管炎 (PSV) 中大脑血管的参与尚未得到充分理解.
- 脑血管事件 (CVEs) 可以显著影响患有PSV的患者.
研究的目的:
- 为了确定在PSV诊断时CVE的频率.
- 为了确定与PSV患者中CVE相关的因素.
- 探索PSV中风的特征和结果.
主要方法:
- 从DCVAS研究中对成年PSV患者的分析.
- 在有和没有CVEs的PSV患者之间比较人口统计数据,血管风险因素和临床特征.
- 评估中风亚型和6个月内复发性CVE的累计发病率.
主要成果:
- 在4828名PSV患者中的3.5%报告了CVEs (102次中风,81次TIA).
- 根据PSV类型的CVE频率有所不同,比赫塞特病 (9.5%),多关节炎 (6.2%) 和塔卡亚苏动脉炎 (6.0%) 的频率最高.
- 在6个月内,PSV患者的复发性CVE累计发病率为11.9%.
结论:
- 在诊断时,CVE影响了大量PSV患者,亚型之间有显著的差异.
- 在PSV中,CVEs不是主要由传统的血管风险因素驱动的.
- 在PSV患者中,CVE复发的风险很高.
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