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深度TMS治疗与IV胺注射用于重大抑郁症的协同使用:试点研究

Nathaniel A Shanok¹, Sabrina Muzac², Leah Brown²

¹Delray Center for Brain Science, Delray Beach, FL, USA. nshanok@delraycenter.com.

Psychopharmacology

|March 13, 2024

概括

深度经磁刺激 (TMS) 有效治疗对其他疗法有抗性的严重抑郁症 (MDD). 在这项研究中,在TMS中添加胺注并没有显著改善治疗反应率.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
临床研究临床研究

背景情况:

大型抑郁症 (MDD) 影响着数以百万计的人,其中很大一部分对标准治疗有抗性.
跨磁刺激 (TMS) 和胺注射是治疗耐药抑郁症的新兴疗法.
有限的研究存在于TMS和胺对MDD的联合疗效.

研究的目的:

为了比较Deep TMS单独治疗的疗效与Deep TMS结合胺注入的疗效,用于治疗耐药性MDD的患者.
评估两种治疗方式的反应和缓解率.

主要方法:

169名患有耐治疗MDD的参与者接受了9周的深度TMS (H1+H7协议).
66名参与者在9周内同时接受了深度TMS和6次静脉胺注射.
抑郁症状在治疗前和治疗后使用PHQ-9尺度进行评估.

主要成果:

只有深度TMS和TMS-胺组都显示出抑郁症状的显著减少.
仅TMS的响应率为76.92%,TMS-胺的响应率为80.30%.
仅TMS的缓解率为39.64%,TMS-胺的缓解率为43.42%,两组之间没有统计学上显著的差异.

结论:

深度TMS显示了治疗耐药性MDD的高响应率.
在这项研究中,添加胺注并没有比单独的TMS提供显著的额外益处.
建议对随机控制设计进行进一步的研究,以证实这些发现.

关键词:

在深度TMS中.胺基氨酸 (ketamine) 是一种可以大型抑郁症主要是抑郁症.

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