在儿童中,腹膜透析相关的腹膜炎的频率和预后
Misaki Akiyama1,2, Koichi Kamei3, Kentaro Nishi1
1Division of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.
Clinical and experimental nephrology
|March 13, 2024
概括
腹膜炎是腹膜透析 (PD) 的常见并发症,最常发生在两岁以下的儿童身上. 伪菌感染显著增加了儿童PD患者的导管切除和治疗失败的风险.
科学领域:
- 儿科脏病学 儿科脏病学
- 传染性疾病 传染性疾病
- 透析治疗 透析治疗
背景情况:
- 腹膜炎是腹膜透析 (PD) 失败的主要原因.
- 关于周周炎风险因素和治疗失败导致儿科PD患者导管切除的数据有限.
研究的目的:
- 为了确定患有腹膜炎的风险因素和由于治疗失败导致的导管切除在儿科PD患者中.
- 分析不同儿科年龄组中腹膜炎的发病率.
主要方法:
- 2002年3月至2022年6月,对患有慢性肺炎的儿科患者进行单一中心的回顾性研究.
- 计算每年患者周周炎发病率,按年龄分层.
- 多变量后勤回归分析,以确定腹膜炎和导管切除的风险因素.
主要成果:
- 整体腹膜炎发病率为0.21个病例/患者年.
- 两岁以下的儿童患病率最高 (0.26次/患者年).
- 腹膜炎和导管切除的主要危险因素是两岁前的PD插入 (OR=2.5) 和Pseudomonas aeruginosa感染 (OR=11.0).
- Pseudomonas aeruginosa 也预测了重新启动PD的困难.
结论:
- 两岁以下的儿科患者表现出腹腔炎发病率最高的情况.
- 伪菌的腹膜炎是导管切除和随后的腹膜功能障碍的重要危险因素,影响PD结果.
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