在受限压缩下皮下组织的多弹性表征和建模
Jacques Barsimantov1, Jordanna Payne2,3, Mario de Lucio1
1School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Annals of biomedical engineering
|March 13, 2024
概括
了解皮下组织机制对于有效的药物输送至关重要. 这项研究描述了组织和水凝的多弹性行为,使得皮下注射的预测模拟成为可能.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 皮下组织机械对于药物输送至关重要,但表征通常忽略了其皮质弹性性.
- 皮下药物输送的进步需要对本地组织和生物仿真水凝进行准确的阴性弹性数据.
研究的目的:
- 描述皮下组织和凝水凝的多弹性机械反应.
- 开发和实施一个构成模型来模拟皮下注射和药物输送.
主要方法:
- 在生理条件下对猪皮下组织和凝水凝进行限制性压缩试验.
- 反向有限元分析,以导出多弹性材料参数 (剪切模量,液压透性等). ) 的情况.
- 在同位几何分析 (IGA) 框架内实现一个孔状超粘弹性新胡克模型.
主要成果:
- 构成模型准确地捕获了局限的压缩反应,包括因流体排水和粘性消散而导致的应力放松.
- 推断的材料参数,特别是液压透性,与文献价值一致.
- IGA模拟预测,在1毫升皮下注射时,峰值应力为48.8千帕,随着药物分散而下降.
结论:
- -超粘弹性新胡克模型有效地描述了皮下组织和水凝机制.
- IGA框架促进了皮下药物递送应用的预测模拟.
- 精确的皮质弹性表征对于优化皮下药物递送系统至关重要.
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