什么时候前期早产新生儿的淋巴细胞过率会赶上他们的期期同龄人?
Yunjiao Wu1, Karel Allegaert2,3, Robert B Flint2,4
1Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, 2333CC, Leiden, The Netherlands.
Pharmaceutical research
|March 13, 2024
概括
早产婴儿的淋巴细胞过率 (GFR) 在三岁左右赶上了满期婴儿的水平. 这一发现表明,对于3岁以下的早产婴儿,调整药物剂量是必要的.
科学领域:
- 儿科脏病学 儿科脏病学
- 药理动力学 药理动力学
- 增长和发展 增长和发展
背景情况:
- 在早产婴儿中,淋巴膜过率 (GFR) 的成熟程度尚不清楚.
- 确定早产婴儿的GFR何时达到与满期婴儿相当的水平,对于适当的药物剂量至关重要.
研究的目的:
- 为从出生到18岁的个体开发一个全面的GFR成熟模型,包括早产和早产婴儿.
- 应用这种GFR模型来预测儿科人群中脏分泌药物的度.
主要方法:
- 结合已发表的胰岛素清除率和血清肌素数据,来自早产和早产儿.
- 开发了一种包含出生时GFR的GFR模型和基于月经后年龄 (PNA) 的Emax模型.
- 通过将GFR模型应用于预测 gentamicin,tobramycin 和 vancomycin 的度来验证GFR模型.
主要成果:
- GFR模型表明,出生时的GFR与出生体重线性相关.
- 月经后的年龄是GFR成熟的关键共变量,妊娠年龄影响PNA50和当前体重影响GFRmax.
- 到三岁时,在26周的婴儿出生时,GFR达到92%的婴儿出生在40周的婴儿.
结论:
- 过早出生婴儿的GFR在大约三岁时达到他们满期出生的同龄人的GFR.
- 对于3岁以下的早产婴儿,应考虑对通过清除的药物进行剂量调整.
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