为慢性淋巴细胞白血病患者优化mHealth行为干预措施:HEALTH4CLL研究
Che Young Lee1, Max J Gordon2, Melissa M Markofski3
1Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd. Unit 1440, Houston, TX, 77030, USA.
Journal of cancer survivorship : research and practice
|March 13, 2024
概括
这项试点研究发现,饮食和体育活动干预显著减少慢性淋巴细胞白血病 (CLL) 患者的疲劳和改善身体功能. 运动和自我监测的结合是这些改善的关键.
科学领域:
- 在瘤学瘤学.
- 运动科学 运动科学
- 行为医学是一种行为医学.
背景情况:
- 慢性淋巴细胞白血病 (CLL) 显著影响患者的生活质量,经常导致衰弱的疲劳和减少的身体功能.
- 目前对CLL的管理策略可能无法完全解决症状负担和功能衰退.
- 需要有效,可访问的干预措施来改善CLL幸存者的福祉.
研究的目的:
- 试验一种饮食和体力活动干预措施 (HEALTH4CLL),旨在减少CLL患者的疲劳和增强CLL患者的身体功能.
- 评估包括运动和行为策略在内的移动健康 (mHealth) 干预措施的可行性和初步有效性.
- 确定最佳的干预组件,以改善患者的治疗结果.
主要方法:
- 使用多相优化策略 (MOST) 的随机因子设计在16周内被采用.
- 参与者接受了教学材料,Fitbit,并被随机分配到16种干预组合中的1种.
- 包括疲劳,身体功能,生活质量和行为变化在内的结果使用对联t测试和因数ANOVA进行了评估.
主要成果:
- 与基线相比,疲劳 (+200911.8) 和身体功能 (+20092.6) 评分有显著改善.
- 抵抗和有氧运动与日常自我监测的组合与减少疲劳有关.
- 与单独的有氧运动相比,阻力加有氧运动对身体功能有了更大的改善.
结论:
- 在CLL患者中,联合有氧和阻力运动计划以及每日自我监测有效地减少了疲劳和改善了身体功能.
- "HEALTH4CLL"试点研究表明,对于CLL幸存者来说,低接触的mHealth干预措施的可行性.
- 作为综合干预的一部分,抵抗运动显示出改善癌症幸存者的症状和生活质量的前景.
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