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植物和关节动物IgE结合的类似帕帕因的氨酸蛋白酶:对过敏性有多种贡献

Ivana Giangrieco¹, Maria Antonietta Ciardiello², Maurizio Tamburrini¹

¹Institute of Biosciences and BioResources (IBBR), National Research Council of Italy (CNR), 80131 Naples, Italy.

Foods (Basel, Switzerland)

|March 13, 2024

概括

类似帕帕因的囊蛋白酶 (PLCPs) 是具有多种应用的必不可少的酶,但可以引发过敏. 它们的活性增加了组织的透性,促进过敏原的进入,导致呼吸道或职业过敏.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
生物技术是生物技术.

背景情况:

类似帕帕因的氨酸蛋白酶 (PLCPs) 是一种被保存的酶家族,在所有生命领域都能找到.
这些蛋白酶与帕帕因具有关键的结构和酶特征,并表现出广泛的基质特异性.
PLCP是众多生物过程中不可或缺的组成部分,并具有重要的生物技术应用.

研究的目的:

为提供帕帕因类囊蛋白酶的一般性质的概述.
突出PLCPs在人类过敏反应中的作用.
区分PLCP诱导过敏的暴露来源和途径.

主要方法:

关于类似帕帕因的氨酸蛋白酶研究的文献综述.
报告的生物功能和生物技术应用的分析.
检查了PLCP介导过敏背后的机制.

主要成果:

PLCPs可以增加组织透性,增强过敏原通过皮肤,肠道和呼吸道屏障的透.
经常观察到对吸入PLCP的过敏,例如虫过敏原Der p1和Der f1.
植物性PLCP通常在胃肠道中被消化,很少引起食物过敏,但可能导致职业病.

结论:

类似帕帕因的氨酸蛋白酶具有双重作用:有价值的生物技术工具和重要的过敏原.
暴露途径和蛋白质来源 (例如,吸入与摄入) 极大地影响了对PLCPs过敏反应的风险和类型.
了解PLCP的特性对于管理过敏和优化其生物技术用途至关重要.

关键词:

过敏原的同类物质.胃肠道消化消化消化吸入的过敏原是可以吸入的.虫蛋白质酶是一种虫蛋白质酶.职业过敏是一种职业过敏.植物食品植物食品蛋白质溶解活动的蛋白质溶解活性.敏感化的敏感化.紧密的交叉路口紧密的连接组织透性组织透性

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