更新狗慢性炎症肠病的分类
Noémie Dupouy-Manescau1, Tristan Méric1, Odile Sénécat1
1Oniris VetAgroBio Nantes, Department of Clinical Sciences, Nantes-Atlantic College of Veterinary Medicine and Food Sciences, 44300 Nantes, France.
Animals : an open access journal from MDPI
|March 13, 2024
概括
目前对犬类慢性炎症性肠道病变 (CIEs) 的分类可能会错误地分类病例. 研究人员提出了一个新的类别,即微生物群相关的调制反应性肠病 (MrMREs),以更好地反映治疗反应和肠道健康.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 狗慢性炎症肠道病变 (CIEs) 按治疗反应分类:对食物有反应 (FREs),对抗生素有反应 (AREs),对免疫抑制剂有反应 (IREs) 和没有反应 (NREs).
- 最近的发现表明,NREs可能被错误分类,一些狗对饮食变化做出反应,可能低估了FREs.
- 人们越来越认识到肠道失生症是CIE病变的一个因素,这促使人们重新评估治疗策略.
研究的目的:
- 建议对犬类CIEs进行改进的分类系统.
- 引入一个新的类别,即微生物群相关调制反应性肠病变 (MrMREs),以取代目前的抗生素反应性肠病变 (AREs) 类别.
- 承认肠道微生物群调节在管理犬类肠道病变中的作用.
主要方法:
- 审查有关犬类CIE分类和治疗反应的现有文献.
- 分析抗生素对有CIE的狗肠道微生物群的影响.
- 基于微生物群调节的新分类类别的概念开发.
主要成果:
- 目前的分类系统可能导致对食物敏感性肠病 (FREs) 的错误分类.
- 在犬类肠道病变中使用抗生素可能会导致抗菌素耐药性和对肠道微生物群的负面影响.
- 从对抗生素的依赖转向恢复肠道微生物群多样性的治疗正在出现.
结论:
- 拟议的微生物群相关调制反应性肠道病变 (MrMREs) 类别为那些条件响应旨在调节肠道微生物群的治疗的狗提供了更准确的分类.
- 这种改进解决了当前抗生素反应性肠道病变 (ARE) 类别的局限性,并与狗CIEs不断发展的治疗方法保持一致.
- 新的分类强调了肠道健康和微生物平衡在控制犬类炎症性肠道疾病中的重要性.
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