在尾瘤患者中治疗的现状 - - 旧的挑战和新的解决方案?
Katarzyna Chawrylak1, Magdalena Leśniewska1, Katarzyna Mielniczek1
1Department of Surgical Oncology, Medical University of Lublin, Radziwiłłowska 13 St., 20-080 Lublin, Poland.
Cancers
|March 13, 2024
概括
尾瘤 (ATs) 存在诊断挑战,神经内分泌新生体是最常见的. 本综述详细介绍了AT的分类,诊断和治疗,并解决了假瘤周周风险.
科学领域:
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
- 在瘤学瘤学.
背景情况:
- 尾瘤 (ATs) 被世界卫生组织分为四类:状病变,粘膜瘤,腺癌和神经内分泌瘤 (NENs).
- 由于稀有性和有限的临床试验数据,诊断ATs具有挑战性,通常在尾切除过程中偶然发现.
- 在欧洲,AT主要影响50岁以上的人 (65%) 和女性 (56.8%),NEN占组织学类型的54.6%.
研究的目的:
- 审查尾瘤的诊断方法,包括分子诊断和分期.
- 概述各种尾瘤的当前治疗策略和预后因素.
- 为了解决管理尾粘膜性瘤及其与膜性伪肌瘤相关的复杂性.
主要方法:
- 关于尾瘤分类,诊断和治疗的综合文献综述.
- 对有关ATS的年龄,性别和组织学分布的流行病学数据的分析.
- 综合有关分子标记物,分期系统和治疗方式的信息.
主要成果:
- 神经内分泌瘤 (NENs) 是最常见的尾瘤 (54.6%),其次是粘膜性瘤 (26.8%) 和腺癌 (18.6%).
- 大多数尾发现都是良性或小的NEN,不需要进一步治疗.
- 尾粘膜性瘤 (AMN) 是一个严重的问题,因为它有可能导致尾瘤 (PMP).
结论:
- 有效管理尾瘤需要对其多样化的分类和诊断挑战有充分的了解.
- 标准化诊断标准和分子分析对于准确的分期和量身定制的治疗至关重要.
- 需要进一步的研究来优化多模式治疗策略,并改善晚期尾瘤患者的治疗结果.
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