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Comparative Lesions Analysis Through a Targeted Sequencing Approach

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Published on: November 5, 2019

在GIST中晚期系统性治疗的结果:序列是否重要?

Prapassorn Thirasastr¹, Thomas L Sutton², Cissimol P Joseph¹

¹Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

|March 13, 2024

概括

这项研究发现,ripretinib和avapritinib都对晚期胃肠道 stromal 瘤 (GIST) 有效. 这些药物的服用顺序不会影响它们的疗效,在GIST治疗顺序中提供灵活性.

科学领域:

在瘤学瘤学.
胃肠道瘤学胃肠道瘤学
胃肠道侧腔瘤 (GISTs) 是一种疾病.

背景情况:

利普雷提尼布和阿瓦普里提尼布是铁激酶抑制剂,用于胃肠道 stromal 瘤 (GISTs) 的后期治疗.
了解这些药物的顺序治疗的疗效对于优化高级GIST患者的治疗结果至关重要.

研究的目的:

在转移性或不可切除的GIST患者中,研究ripretinib之后的avapritinib与avapritinib之后的ripretinib的疗效.
根据药物使用顺序,比较进展时间 (TTP) 和总生存期 (OS).

主要方法:

在两个机构对34名转移/无法切除的GIST患者进行了回顾性分析,这些患者接受了ripretinib和avapritinib治疗.
患者被分为ripretinib-avapritinib (RA) 和avapritinib-ripretinib (AR) 序列.患者被分为两组.
用RECIST 1.1评估的放射反应;使用Kaplan-Meier和log-rank测试分析的TTP和OS.

主要成果:

在RA和AR组之间,基线特征或瘤突变没有显著差异.
对ripretinib (18%的RA对12%的RA) 和avapritinib (12%的RA对18%的RA) 的反应率相似.
在RA和AR序列之间,中位数TTP和OS是可比的,表明不依赖药物顺序.

结论:

利普利提尼布和阿瓦普利提尼布都在GIST的晚期治疗中表现出有效性.
服用ripretinib和avapritinib的顺序似乎不会影响GIST患者的治疗疗效.
这些发现支持治疗灵活性,用于对高级GIST进行这些药物的测序.

关键词:

这就是阿瓦普里提尼布.胃肠道胃瘤是什么里普雷丁尼布 (ripretinib) 是一种药物.

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