异型子宫内膜增生和并发性癌症:对具有挑战性的临床条件的全面概述
Luca Giannella1, Camilla Grelloni1, Marco Bernardi1
1Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, 60123 Ancona, Italy.
Cancers
|March 13, 2024
概括
非典型子宫内膜异位增生 (AEH) 审查确定了隐性子宫内膜癌 (EC) 的危险因素,并发现透切除最适合采样. 不建议对AEH进行淋巴结评估.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 非典型子宫内膜增生 (AEH) 呈现出诊断上的挑战,并存在子宫内膜癌 (EC) 的风险.
- 准确的风险分层和适当的诊断方法对于管理AEH患者至关重要.
- 了解临床因素的预测价值和采样技术的有效性至关重要.
研究的目的:
- 审查AEH管理中的关键辩论因素,包括神秘EC的预测因素.
- 通过不同的子宫内膜采样方法来评估EC低估率.
- 在AEH中评估淋巴结状况评估的适当性.
主要方法:
- 对有关非典型子宫内膜异位增生和子宫内膜癌的文献进行系统审查.
- 对隐性子宫内膜癌的预测变量的分析.
- 对子宫内膜采样方法的比较,重点是对子宫内膜切除术 (Hys-res).
- 在AEH患者中评估淋巴结阳性率.
主要成果:
- 高龄,糖尿病,高BMI和子宫内膜厚度增加与EC有关,但预测能力有限.
- 透透视膜内膜切除 (Hys-res) 显示了最低的EC低估率 (6-11%).
- 在AEH中淋巴结阳性率为2.3%,由于成本/风险/收益方面的担忧,不支持其常规使用.
结论:
- 需要对更大的队列进行进一步的研究,以验证Hys-res对AEH的疗效.
- 目前的数据不支持对AEH的常规淋巴结评估.
- 准确的诊断和风险分层对于最佳的AEH患者管理至关重要.
更多相关视频
相关概念视频
Disorders of the Female Reproductive System
358
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
358
Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Cancer
48.5K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
48.5K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K


