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Updated: Jul 1, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

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CPX-351 血液恶性病和功能障碍的成年人中的药理动力学和安全性:第一阶段试验

Scott R Solomon1, Bayard L Powell2, Jamie Koprivnikar3

  • 1Bone & Marrow Transplant (BMT), Leukemia and Cellular Immunotherapy Programs, Northside Hospital Cancer Institute, Atlanta, GA 30342, USA.

Cancers
|March 13, 2024
PubMed
概括

CPX-351的药理动力学和安全性在患有血液恶性瘤和功能变化的患者中进行了评估. 在中度或重度功能障碍患者中,不需要对CPX-351进行剂量调整.

关键词:
在CPX-351中使用.血液癌症是血液癌症.药物动力学 药物动力学患有功能障碍的人.

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The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
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