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在瘤学中的调节疗法中,外体细胞是有前途的载体
Teresa Maria Jóźwicka1, Patrycja Maria Erdmańska1, Agnieszka Stachowicz-Karpińska2
1Department of Oncology, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Torun, Poland.
Cancers
|March 13, 2024
概括
细胞外囊泡 (EVs),特别是外体,在癌症中促进细胞间通信,促进瘤的进展和免疫逃避. 工程外体通过调节瘤微环境,为向癌症治疗提供治疗潜力.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 纳米技术 纳米技术
背景情况:
- 细胞外囊泡 (EVs),包括外体,是纳米粒子,在生理和病理过程中对细胞间通信至关重要.
- 在癌症中,EVs调解分子的转移,促进血管生成,转移和免疫逃避.
- 了解EV的作用对于开发新型癌症疗法至关重要.
研究的目的:
- 审查了解外体细胞如何影响瘤进展和瘤微环境的最新进展.
- 突出工程外体在癌症治疗中的治疗潜力.
- 讨论目前在外体隔离,表征和工程方面的技术和挑战.
主要方法:
- 关于癌症中的外体细胞功能当前文献的综述.
- 对瘤进展中的外体介导机制的分析 (例如,EMT,巨细胞两极分化,免疫抑制).
- 对治疗应用的外体工程策略的讨论.
主要成果:
- 外基因组诱导上皮层-介质细胞过渡,促进前瘤巨细胞表型,并抑制抗瘤免疫力.
- 工程外体可以装载药物,RNA疗法或瘤抗原来修改瘤微环境.
- 讨论了当前的隔离,表征和工程技术,以及加载效率,生物分布和准方面的挑战.
结论:
- 外体提供有前途的途径,以了解瘤发生和开发有针对性的诊断和治疗策略.
- 通过外体利用自然的细胞间通信网络,为传统的癌症治疗提供了可行的替代方案.
- 使用外体的调节疗法有可能为癌症发展创造不利的条件.
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