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Updated: Jul 1, 2025

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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在γ-分泌酶的活性部位中的β-粉样基质的形状变化和展开

Jakub Jakowiecki1, Urszula Orzeł1, Przemysław Miszta1

  • 1Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 02-093 Warsaw, Poland.

International journal of molecular sciences
|March 13, 2024
PubMed
概括

这项研究探讨了粉样蛋白前体蛋白 (APP) 碎片,特别是粉样β (Aβ) ,如何在γ-分泌酶中改变形状. 结果揭示了基质灵活性的差异,这可能解释了为什么某些Aβ形式更容易在阿尔茨海默病 (AD) 中形成斑块.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.贝塔氨基化物-贝塔氨基化物玛分泌酶的产生膜蛋白质溶解是一种膜蛋白质溶解.基板的剪裁 基板的剪裁

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