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在多发性硬化症的发展和进展中选择性介质蛋白的作用 - 一个系统性审查

Cezary Grunwald¹, Anna Krętowska-Grunwald², Edyta Adamska-Patruno³

¹Department of Neurology, Medical University of Bialystok, Marii Skłodowskiej-Curie 24A, 15-276 Białystok, Poland.

International journal of molecular sciences

|March 13, 2024

概括

互白蛋白 (ILs) 在多发性硬化症 (MS) 的发展和进展中起着关键作用. 了解这些细胞因子的作用,如IL-10

科学领域:

神经免疫学神经免疫学
炎症和神经系统疾病

背景情况:

多发性硬化症 (MS) 是一种慢性,致残的中枢神经系统炎症性疾病.
目前的MS治疗重点是减少复发,减缓身体和认知能力的下降.
细胞因子介导的自身免疫过程与MS的发病和复发有关.

研究的目的:

审查特定白细胞间蛋白 (ILs) 在多发性硬化症的发病和进展中的作用.
探索IL血清水平,基因多态和MS活动之间的关联.
讨论在MS治疗中准IL的治疗潜力.

主要方法:

文献综述总结了有关白细胞间蛋白和多发性硬化症的现有研究.
对报告MS患者血清IL水平与对照研究的分析.
检查IL基因多态性作为MS风险因素的研究.

主要成果:

在活跃的MS阶段观察到IL-2,IL-4,IL-6,IL-13,IL-17,IL-21,IL-22和IL-33的血清水平升高.
介质蛋白-10 (IL-10) 显示出对抗多发性硬化症进展的潜在保护作用.
IL-13,IL-22和IL-33表现出神经保护作用,尽管有助于炎症的关联.
在IL-2R,IL-4,IL-6,IL-13和IL-22中的基因多态性与MS发展风险有关.

结论:

特定的互白蛋白与多发性硬化症的活动和进展有显著的关联.
由于它们在MS中的作用,IL-10,IL-13,IL-22和IL-33具有潜在的治疗点.
准细胞因子通路为未来的多发性硬化症治疗策略提供了有希望的途径.
进一步的研究是必不可少的,以充分阐明在MS的ILs的复杂机制.

关键词:

自身免疫性疾病是一种自身免疫性疾病.细胞因子细胞因子实验性的自身免疫性脑膜炎.它们包括interleukins和interleukins.多发性硬化症多发性硬化症

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