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用于口腔癌检测的唾液生物标志物:一个探索性的系统性审查

Daniel Bastías¹, Alejandro Maturana¹, Constanza Marín¹

¹Unit of Oral Pathology and Oral Medicine, Faculty of Dentistry, Universidad Andres Bello, Viña del Mar 2520000, Chile.

International journal of molecular sciences

|March 13, 2024

概括

唾液含有可以帮助早期诊断口腔癌的分子. 像TNF-α和IL-1β这样的关键生物标志物显示出有希望的结果,但临床使用需要更大规模的研究.

科学领域:

生物化学生物化学
在瘤学瘤学.
分子诊断学分子诊断学

背景情况:

口腔癌的诊断和预测需要少入侵的方法.
唾液正在被探索作为潜在的诊断生物标志物的来源.
口腔状细胞癌 (OSCC) 仍然是一个重大的健康问题.

研究的目的:

进行唾液分子作为OSCC诊断的潜在生物标志物的范围审查.
识别唾液中的分子,用于早期检测口腔癌.
根据诊断和预后能力对生物标志物进行分类.

主要方法:

在主要数据库 (EBSCO,PubMed,Scopus,Web of Science) 中进行了全面的文献搜索.
包括的研究评估了唾液分子用于OSCC诊断和预测.
分析了62项评估100多个分子的研究.

主要成果:

超过100个唾液分子被评估为OSCC和口腔潜在恶性疾病 (OPMDs).
最常被研究的是瘤缩因子-α (TNF-α),互白蛋白 (IL-1β,IL-6,IL-8),乳酸脱酶 (LDH) 和矩阵金属蛋白酶-9 (MMP-9).
大多数研究报告这些有前途的唾液生物标志物的高灵敏度和特异性.

结论:

TNF-α,IL-1β,IL-6,IL-8,LDH和MMP-9是早期OSCC检测的有希望的唾液生物标志物.
需要对更大患者队伍进行进一步的研究.
这些唾液生物标志物的临床转化需要在广泛的研究中得到验证.

关键词:

生物标志物生物标志物口腔瘤的新生体.口腔癌是指口腔癌的发生.口腔潜在的恶性疾病.这是唾液,唾液.

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