母亲在月经期的年龄 基因决定胎儿生长 限制风险
Evgeny Reshetnikov1, Maria Churnosova1, Yuliya Reshetnikova1
1Department of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, Russia.
International journal of molecular sciences
|March 13, 2024
概括
母亲初潮时的年龄 (mAAM) 基因变异与胎儿生长限制 (FGR) 风险有关. 这项研究确定了影响FGR发育的特定mAAM基因多态,为怀孕并发症提供了新的见解.
科学领域:
- 遗传学和产科 遗传学和产科
- 生殖医学 生殖医学
背景情况:
- 胎儿生长限制 (FGR) 是一个主要的产科并发症.
- 初潮时的母亲年龄 (mAAM) 影响生殖健康.
- FGR的遗传基础及其与mAAM的关系尚未完全理解.
研究的目的:
- 调查mAAM基因多态和FGR的风险之间的关联.
- 确定FGR中的特定遗传变异及其功能影响.
主要方法:
- 一项涉及904名妇女的病例控制研究 (273名FGR,631名对照).
- 50个候选mAAM单核酸多态 (SNP) 的基因定型.
- 使用后勤回归和基于模型的多因素缩小维度 (MB-MDR) 的统计分析.
- 在特定位置的In silico功能评估.
主要成果:
- 三个mAAM位点 (KISS1,NKX2-1,GPRC5B) 与FGR风险有显著的联系.
- 在FSHB基因中的ACA单元型显示与FGR的相关性.
- 涉及13个SNP的基因相互作用显著影响了FGR风险,特别是rs999460 (NKX2-1) 和rs12444979 (GPRC5B).
- 确定了15种与FGR相关的mAAM变异和350个关联的SNP,影响39个参与激素调节,排卵和维生素D代谢的基因.
结论:
- 这项研究提供了第一个证据,即mAAM相关的基因有助于FGR风险.
- 特定的mAAM基因多态和它们的相互作用是FGR的潜在生物标志物.
- 研究结果强调了遗传因素在早期生殖事件和怀孕结果中的作用.
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