慢性病的新视角 - 特定的心血管疾病
Cuicui Xu1, George Tsihlis2, Katrina Chau3,4
1Kidney Injury Group, Centre for Transplant and Renal Research, Westmead Institute for Medical Research, 176 Hawkesbury Road, Westmead, NSW 2145, Australia.
International journal of molecular sciences
|March 13, 2024
概括
慢性病 (CKD) 加快了心血管疾病 (CVD) 的风险,导致心脏综合征 (CRS). 了解共享的分子通路为向治疗和早期检测提供了潜力.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 分子生物学分子生物学
背景情况:
- 慢性病 (CKD) 影响全球10%以上的成年人,显著增加心血管疾病 (CVD) 的风险.
- 在CKD患者中,心血管疾病是过早和加速的,包括冠状动脉疾病,心力衰竭和心律失常等疾病.
- 心脏病综合征 (CRS) 产生于CKD和CVD的相互作用,由共同的风险因素和双向器官恶化驱动.
研究的目的:
- 审查对心综合征 (CRS) 的不断发展的理解.
- 为突出CRS分子生物学近期的进展.
- 概述潜在的疾病特异性疗法和生物标志物用于CRS检测.
主要方法:
- 文献综述侧重于CRS的分子病理生理学.
- 分析CKD和CVD中共享的风险因素和机制.
- 综合关于CRS炎症,氧化应激和衰老的当前知识.
主要成果:
- 共同的风险因素,如高血压,糖尿病,肥胖和脂质失调,有助于CRS.
- 神经激素激活,炎症和免疫反应加剧心脏和脏损伤.
- 常见的分子通路包括炎症,氧化应激,衰老和血液动力学变化是CRS的特征.
结论:
- CRS涉及心脏和脏系统之间的复杂相互作用.
- 了解分子病理生理学是开发针对CRS的向治疗的关键.
- 在CRS中,早期检测和风险分层的生物标志物至关重要.
相关概念视频
01:22Heart Failure Drugs: Diuretics
370
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
370
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
428
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
428
01:29Renal Regulation of Acid-Base Balance
430
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
430
01:06Renal Drug Clearance: Overview
188
Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
188
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
81
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
81
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K