交叉路径:非酒精性脂肪性肝病和牛皮双重综合性审查-A综合性审查
Daniel Octavian Costache1,2, Horia Blejan2, Damian Lucian Cojocaru3
1Discipline of Dermatology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
International journal of molecular sciences
|March 13, 2024
概括
牛皮和非酒精性脂肪性肝病 (NAFLD) 具有共同的炎症途径. 建议在牛皮患者中早期查NAFLD,以改善患者的治疗结果.
科学领域:
- 皮肤病学和肝病学.
- 免疫学和代谢疾病
背景情况:
- 牛皮是一种慢性炎症性疾病,影响生活质量.
- 牛皮与诸如心血管疾病,牛皮关节炎和代谢综合征等并发症有关.
- 非酒精性脂肪性肝病 (NAFLD) 很普遍,并通过炎症和胰岛素抵抗与牛皮有关.
研究的目的:
- 审查牛皮和NAFLD之间的病理生理联系.
- 为了引入"肝皮轴"概念.
- 讨论对查和治疗的临床影响.
主要方法:
- 关于病理生理学联系的文献综述.
- 重点是炎症调解剂 (细胞因子,基因).
- 讨论当前和新兴的指导方针.
主要成果:
- 共同的机制包括慢性炎症和胰岛素抵抗.
- "肝皮轴"描述了双向的肝脏和皮肤炎症.
- 新的指导方针建议对牛皮患者进行透氨酶和超声波查.
结论:
- 了解牛皮-NAFLD关系,可以深入了解共享机制.
- 临床实践应该包括在中度至重度的牛皮中进行NAFLD查.
- 这些知识指导治疗决策和治疗发展.
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