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相关概念视频

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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探索骨髓干细胞与肥胖之间的相互作用

Fiorenzo Moscatelli1, Antonietta Monda2, Giovanni Messina2

  • 1Department of Wellbeing, Nutrition and Sport, Pegaso Telematic University, 80143 Naples, Italy.

International journal of molecular sciences
|March 13, 2024
PubMed
概括

肥胖症涉及过度的脂肪积累和炎症. 骨髓干细胞影响脂肪形成和代谢平衡,突出显示了这种慢性疾病中复杂的相互作用.

关键词:
脂肪组织的脂肪组织.骨髓 骨髓 骨髓 骨髓 骨髓这是一种炎症炎症炎症炎症.介质细胞干细胞介质细胞干细胞肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖干细胞是干细胞的组成部分.

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科学领域:

  • 生物医学科学 生物医学科学
  • 干细胞生物学 干细胞生物学
  • 代谢障碍 代谢障碍 代谢障碍

背景情况:

  • 肥胖是一种复杂的,慢性,炎症性疾病,其特点是脂肪组织的过度积累.
  • 脂肪组织是一个多样化的器官,受个体特征和位置的影响.
  • 新兴研究探讨了骨髓干细胞与肥胖之间的联系.

研究的目的:

  • 审查有关骨髓干细胞与肥胖之间的关系的当前研究.
  • 在肥胖的背景下阐明骨髓在脂肪生成和炎症中的作用.

主要方法:

  • 现有科学文献的叙述性审查.
  • 对调查骨髓干细胞分化和肥胖症骨髓微环境的研究进行分析.

主要成果:

  • 骨髓中介酶干细胞对于脂肪生成 (脂肪细胞形成) 是至关重要的.
  • 肥胖可能会改变骨髓的微环境,影响干细胞分化和脂肪储存.
  • 骨髓的免疫功能使其在肥胖中的作用更加复杂.

结论:

  • 骨髓干细胞在脂肪生成和代谢平衡中发挥着重要作用.
  • 骨髓微环境是肥胖发展和进展的关键因素.
  • 需要进一步的研究才能充分理解骨髓与肥胖之间的多方面的联系.