在皮层基底退化中与年龄相关的病理学
Maya Mimuro1,2, Yasushi Iwasaki2
1Department of Pathology, Mie University Hospital, Tsu 514-8507, Japan.
International journal of molecular sciences
|March 13, 2024
概括
皮层骨干退化 (CBD) 的大脑表现出常见的与衰老相关的蛋白质病变,如团和β-粉样蛋白. 这些发现表明,CBD与老年人的其他神经退行性疾病之间有共同的途径.
科学领域:
- 神经病理学神经病理学
- 神经退行性疾病 神经退行性疾病
- 老化的大脑老龄化
背景情况:
- 老年人的大脑容易受到各种蛋白质病变的影响,每一种都有不同的传播途径.
- 陶型免疫反应性星体细胞在老年大脑中很常见.
- 星状细胞斑块是皮层细胞底性退化 (CBD) 的特征,在衰老和其他神经退行性疾病中并不常见.
研究的目的:
- 为了研究与衰老相关的病理和皮质皮质退行 (CBD) 之间的临床病理关系.
- 为了检查在病理确认的CBD病例中常见蛋白质病变的同时发生.
主要方法:
- 对21例病理确诊的皮质骨干退行症 (CBD) 病例的分析.
- 组织病理学检查神经纤维状结 (NFT),谷物,β-粉样沉积,莱维体和TDP-43蛋白质病变.
- 观察到的病理与临床和人口统计数据的相关性.
主要成果:
- 所有21个CBD病例都表现出颗粒和神经纤维状结 (NFT).
- 在71.4%的病例中存在β-粉样蛋白沉积,在14.3%的病例中存在Lewy体病理.
- 临主导和与年龄相关的TDP-43脑病变 (LATE) 在23.8%的病例中被观察到,在临系统中发现了NFT,谷物和TDP-43入.
结论:
- 皮层骨干退化 (CBD) 经常与常见的与衰老相关的蛋白质病变同时发生.
- 在CBD中NFT,谷物和TDP-43含量的分布表明与老化大脑中的其他蛋白质病变共享细胞脆弱性和传播途径.
- 这些发现突显了老年大脑中蛋白质病变的复杂相互作用,以及它们在皮质细胞底层退化中的潜在重叠.
相关概念视频
Parkinson's Disease: Overview
541
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
541
Alzheimer's Disease: Overview
475
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
475
Aging
51
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
51
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Lysosomal Hydrolases
3.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.8K


