混合维生素补充剂改善了老年小鼠的空间认知和短期记忆
Koji Fukui1, Fukka You2,3, Yugo Kato1
1Molecular Cell Biology Laboratory, Department of Bioscience and Engineering, College of System Engineering and Science, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama 337-8570, Japan.
International journal of molecular sciences
|March 13, 2024
概括
混合抗氧化剂补充剂改善了老年小鼠的认知功能和身体耐力. 这表明与年龄相关的衰退有潜在的益处,但需要进一步的研究.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 神经科学是一个神经科学.
背景情况:
- 抗氧化剂补充剂可以有益,但最佳组合和剂量对于消费者来说尚不清楚.
- 衰老与认知能力下降和身体能力下降有关.
研究的目的:
- 研究混合抗氧化剂补充剂对老年小鼠认知功能和身体表现的影响.
- 为消费者提供有关抗氧化剂补充剂的基于证据的信息.
主要方法:
- 18个月大的C57BL/6小鼠接受了一个月的混合补充剂.
- 用莫里斯水迷宫和Y迷宫来评估认知功能.
- 通过跑步机测试来评估身体耐力.
- 血清生物化学分析是死后进行的.
主要成果:
- 补充剂治疗的小鼠在空间认知和短期记忆方面显著改善 (自发替代比率从49.5%增加到68.67%,p < 0.01).
- 跑步机测试结果表明,补充剂后跑步距离显著增加 (增加11.4%与91.17%,p <0.04).
- 血清分析显示,阿斯巴酸氨基转移酶,氨基转移酶和总胆固醇水平下降.
结论:
- 持续服用混合补充剂可能会提高老年人的认知功能.
- 补充剂可能有助于抑制与年龄相关的肌肉衰退,并提高身体耐力.
- 没有观察到神经营养因子 (如神经生长因子 (NGF) 或来自大脑的神经营养因子 (BDNF) 的显著变化.
相关概念视频
Cognitive Development During Adulthood
98
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
98
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
123
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
123


