COVID-19对脂肪组织特征的影响
Sontje Krupka1, Anne Hoffmann1, Mariami Jasaszwili2
1Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany.
International journal of molecular sciences
|March 13, 2024
概括
冠状病毒疾病-19 (COVID-19) 感染缩小脂肪细胞,影响基因表达更多的是皮下脂肪组织. 这项研究揭示了COVID-19的存在.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢疾病 代谢疾病
- 病理学 病理学 病理学
背景情况:
- 肥胖是严重的COVID-19结果的一个危险因素.
- 脂肪细胞 (脂肪细胞) 可能影响COVID-19的严重程度.
- COVID-19 感染和疫苗接种对脂肪组织的影响尚不清楚.
研究的目的:
- 研究COVID-19感染和疫苗接种对脂肪组织 (AT) 生物学的影响.
- 为了分析COVID-19暴露后AT的组织学,转录学和蛋白质学变化.
- 了解在肥胖个体中AT变化和COVID-19严重程度之间的关系.
主要方法:
- 来自莱比锡肥胖生物库的27个配对的内脏和皮下脂肪组织活检的分析.
- 将捐赠者分为三组:没有感染/没有接种疫苗,没有感染/接种疫苗,感染/接种疫苗.
- 综合组织学,转录组和血清蛋白质组分析.
主要成果:
- COVID-19 感染与较小的平均脂肪细胞大小有关.
- 针对感染的基因表达变化在皮下AT中更为明显,主要涉及免疫系统过程.
- 血清蛋白质组分析发现了阿迪波内克丁,互白素-6 (IL-6) 和碳酸无水酶5A (CA5A) 的变化.
结论:
- COVID-19 感染改变了脂肪组织生物学,显著减少了脂肪细胞的大小.
- 皮下脂肪组织对感染表现出更强的转录反应,与免疫通路有关.
- 观察到的阿迪波涅丁和IL-6等循环蛋白质的变化可能会导致COVID-19肥胖患者的代谢失调.
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