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干细胞在伤口愈合中的有效性:系统性审查

Banu Farabi^1,2,3, Katie Roster⁴, Rahim Hirani⁴

¹Department of Dermatology, New York Medical College, Valhalla, NY 10595, USA.

International journal of molecular sciences

|March 13, 2024

概括

干细胞疗法,特别是脂肪组织衍生的介质干细胞 (AD-MSCs),显示了慢性伤口愈合的前景. AD-MSCs通过促进血管生成和释放生长因子来增强组织修复,从而导致更好的结果.

科学领域:

再生医学是一种再生医学.
伤口愈合生物学伤口愈合生物学
基于细胞的治疗方法

背景情况:

伤口愈合是一种复杂的生物过程,涉及细胞相互作用和信号传递.
伴随性疾病会影响愈合,导致慢性伤口和增加发病率.
干细胞疗法提供了一种潜在的策略,以增强伤口修复机制.

研究的目的:

系统地审查关于用于慢性伤口愈合的干细胞治疗的临床和翻译文献.
确定最佳的干细胞来源和输送方法,以改善伤口修复.
评估干细胞应用在各种慢性伤口类型中的疗效.

主要方法:

在主要数据库 (PubMed,Embase,Web of Science,Google Scholar,Cochrane Library) 进行系统的文献搜索.
包括22,454篇文章,44项研究在严格选后被选中.
对创伤愈合中的干细胞疗法的临床,转化和初级研究进行分析.

主要成果:

脂肪组织衍生中酶干细胞 (AD-MSCs) 由于可用性,易于分离和亲血管性质,被确定为首选来源.
AD-MSCs在治疗各种慢性伤口,包括糖尿病,静脉和术后伤口方面表现出有效性.
各种输送方法 (局部,支架,PRP,甲基合物) 与局部护理相结合,改善了愈合时间,减少了疼痛,并增强了美容效果.

结论:

干细胞移植,特别是使用AD-MSCs,是慢性和难治伤口的有前途的辅助疗法.
移植的干细胞分化并分泌促进血管生成和组织再生的因素.
这种方法有可能降低医疗保健成本并改善患者在伤口护理中的生活质量.

关键词:

慢性伤口慢性伤口皮肤学皮肤学干细胞是干细胞的组成部分.伤口愈合伤口愈合

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