孕期体重增加:遗传变异的作用是一个决定因素吗? 一个审查 一个审查
Reyna Sámano1,2, Hugo Martínez-Rojano3, Gabriela Chico-Barba1
1Coordinación de Nutrición y Bioprogramación, Instituto Nacional de Perinatología, Secretaría de Salud, Mexico City 11000, Mexico.
International journal of molecular sciences
|March 13, 2024
概括
孕期体重增加受遗传学和环境的影响. 这次审查发现对影响GWG的特定基因型变异的证据有限,这表明饮食等环境因素起着更大的作用.
科学领域:
- 生殖健康 生殖健康
- 遗传学 遗传学 是一个
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 过度或不足的妊娠体重增加 (GWG) 与不良的孕产妇和新生儿结局有关.
- 妊娠前体重指数 (pBMI) 与GWG有关,但遗传基础仍然不清楚.
研究的目的:
- 审查和分析可能与妊娠体重增加 (GWG) 相关的基因型变异.
主要方法:
- 对调查基因型变异和GWG的研究进行系统审查.
- 对不同人群和妊娠前BMI类别中的遗传关联的分析.
主要成果:
- 确定了七种基因型变异,可能与GWG调节有关.
- 关联因种族和妊娠前BMI而异;一些变体与肥胖/超重女性的GWG有关.
- 环境因素,特别是饮食,对GWG产生了重大影响,往往超过了遗传贡献.
结论:
- 有限的证据支持在超重/肥胖率高的人群中,特定的基因型变异和GWG之间存在强烈的关联.
- 孕期体重增加似乎更多地受到环境因素的影响,而不是遗传变异.
- 建议对遗传变异,细胞因子及其与pBMI,饮食和种族等混因素的相互作用进行进一步的研究.
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