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在糖尿病视网膜病变的发展中TGF-β信号通路

Andrew Callan¹, Sonal Jha¹, Laura Valdez¹

¹School of Medicine, The University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.

International journal of molecular sciences

|March 13, 2024

概括

糖尿病视网膜病变 (DR) 是一种神经血管疾病,而不仅仅是微血管疾病. 转化生长因子-β (TGF-β) 信号通路是DR病变的关键,并提供潜在的治疗点.

科学领域:

眼科医生眼科眼科
内分泌学在内分泌学.
分子生物学分子生物学

背景情况:

糖尿病视网膜病变 (DR) 是糖尿病的一个主要并发症,影响全球数百万人.
传统上被视为一种微血管疾病,DR日益被认为是一种复杂的神经血管疾病.
氧化应激和先进的糖化终产物对DR的病原产生有显著的贡献.

研究的目的:

审查转化生长因子-β (TGF-β) 信号超级家族在糖尿病视网膜病变中的多方面的作用.
阐明涉及TGF-β的复杂信号网络,其子家族 (例如,BMPs),以及DR中的相关因素.
突出了解这些途径的潜力,以开发新的DR疗法.

主要方法:

文献综述侧重于TGF-β超级家族在糖尿病视网膜病变中的信号传导.
对TGF-β,BMP,氧化应激和非编码RNA在DR中的作用的现有证据的分析.
综合了关于DR病变发生的神经血管和免疫方面的信息.

主要成果:

在DR中,TGF-β信号传递对视网膜血管平衡,内皮功能和细胞周细胞行为至关重要.
BMP子家族在DR中表现出复杂的,取决于背景的亲血管和抗血管原作用.
TGF-β,活性氧物种 (ROS),非编码RNA和炎症之间的相互作用与DR进展有关.

结论:

糖尿病视网膜病变的发病包括由TGF-β超级家族信号驱动的复杂的神经血管机制.
准TGF-β通路及其相互作用为未来的DR治疗提供了一个有希望的策略.
对这些信号网络的全面了解对于减轻DR及其并发症至关重要.

关键词:

在TGF-β的基础上.骨形态蛋白质是骨形态蛋白质的组成部分.细胞信号传递是细胞的信号传递.在糖尿病中,糖尿病是血糖性糖尿病.糖尿病视网膜病变糖尿病视网膜病变有活性氧物种的反应性氧物种.视网膜视网膜视网膜是一个转变的增长因子-β.

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