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磁性刺激肌肉的分泌体表现出抗癌功效:新型预先调节方法突出HTRA1的作用

Yee Kit Tai^1,2,3,4, Jan Nikolas Iversen^1,2,3, Karen Ka Wing Chan^1,2,3

¹Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

|March 13, 2024

概括

脉冲电磁场 (PEMFs) 影响肌肉细胞介质,产生强大的抗癌分泌物. 这种PEMF受条件的介质在体外和体内有效地抑制乳腺癌的生长,迁移和血管性.

科学领域:

生物医学工程生物医学工程
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

肌肉细胞释放出可以影响癌症进展的分泌物.
脉冲电磁场 (PEMF) 是一种非侵入性的物理刺激.
了解肌肉分泌物调节具有治疗癌症的潜力.

研究的目的:

为了调查PEMF刺激肌肉细胞是否会产生抗癌分泌物.
为了评估PEMF受条件介质 (pCM) 在体外和体内对乳腺癌的疗效.
为了确定负责抗癌效应的秘密体内的关键因素.

主要方法:

C2C12神经管被暴露在低振幅的PEMF中以产生pCM.
乳腺癌细胞在体外用pCM进行治疗,以评估生长,迁移和侵入性.
蛋中的乳腺癌微瘤用pCM治疗,以评估瘤体积和血管性.
确定HTRA1是PCM抗癌作用的关键调解者.

主要成果:

与对照介质 (cCM) 相比,PEMF受条件介质 (pCM) 显著抑制了乳腺癌细胞的生长,迁移和侵入性.
在蛋模型中,pCM治疗减少了瘤体积和血管性.
来自暴露于PEMF或炼小鼠的血清也显示出抗癌特性.
在pCM中,HTRA1被上调,对于其抗癌活性来说,它既必要又足够.

结论:

简短的PEMF刺激可以使肌肉细胞的秘密体产生强大的抗癌作用.
这种PEMF诱导的秘密分子调节为癌症治疗提供了一种新的,非侵入性的策略.
HTRA1是抗癌分泌体反应中的一个关键的效应分子.

关键词:

对于PEMF来说,这是一个很好的方法.氨基糖化物抗生素是一种抗生素.乳腺癌乳腺癌乳腺癌有条件的媒体.运动就是炼身体.炼皮肤运动皮肤转移转移转移转移肌痛的原因是myokines.蛋白质组学蛋白质组学可溶性的生物标志物.

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